| Welcome • 1-boc Piperazine |
| 28.06.2025, 04:18 - samir - Rank 1 - 3 Posts
Introduction 1-Boc Piperazine is a widely used chemical intermediate in pharmaceutical research, known for its role in the synthesis of a wide variety of bioactive molecules. The compound features a piperazine ring protected by a Boc (tert-butoxycarbonyl) group, which enhances its stability and selectivity in multi-step synthetic procedures. Chemical Identity IUPAC Name: 1-(tert-Butoxycarbonyl)piperazine CAS Number: 57260-71-6 Molecular Formula: C9H18N2O2 Molecular Weight: 186.25 g/mol Appearance: White to off-white crystalline powder Solubility: Soluble in common organic solvents such as dichloromethane, methanol, and acetonitrile Structural Features 1-Boc Piperazine consists of a six-membered piperazine ring, where one nitrogen is protected with a tert-butoxycarbonyl (Boc) group. This protection: Enhances the selective functionalization of the second nitrogen Provides stability under basic conditions Is easily removed under acidic conditions, making it ideal for stepwise synthesis Applications of 1-Boc Piperazine 1. Pharmaceutical Intermediate It is a key building block in the synthesis of several classes of drugs, including: Antipsychotics Antidepressants Anti-inflammatory agents Anti-cancer compounds The Boc group allows for temporary protection during multi-step synthesis, enabling the development of diverse heterocyclic scaffolds. 2. Medicinal Chemistry and Drug Discovery 1-Boc Piperazine is commonly used in combinatorial chemistry and lead optimization, offering: Increased lipophilicity Improved pharmacokinetic properties Potential for receptor binding enhancement 3. Custom Peptidomimetic Synthesis In the design of peptidomimetics, 1-Boc Piperazine serves as a flexible spacer or scaffold that mimics peptide bonds, useful in: Enzyme inhibitors Signal transduction mimics Receptor ligands Handling and Safety Hazards: May cause skin or eye irritation Precautions: Handle with gloves and eye protection; avoid inhalation or prolonged exposure Storage Conditions: Store in a tightly sealed container, in a cool, dry place away from acids Packaging and Supply Available in: Small Packs: 5g, 25g, 100g for research use Bulk Quantities: 1kg, 5kg, and custom volumes for commercial production Supplied with COA, MSDS, and global shipping options. Conclusion 1-Boc Piperazine is a cornerstone intermediate in the field of organic and medicinal chemistry. Its versatility, ease of use, and clean deprotection make it a preferred choice for researchers and manufacturers developing advanced drug candidates and custom molecules. Need bulk or custom-packed 1-Boc Piperazine? Contact us for quotations, technical documentation, and application support tailored to your R&D or production goals. |